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A plant flavonol and genetic suppressors rescue a pathogenic mutation associated with kinesin in neurons A plant flavonol and genetic suppressors rescue a pathogenic mutation associated with kinesin in neurons
Apr .27.2025
Significance
This study offers important insights into KIF1A-associated neurological disorder (KAND), a group of neurological disorders connected to KIF1A, a microtubule-based motor protein responsible for axonal transport. With limited therapeutic optio
Stress dynamically modulates neuronal autophagy to gate depression onset Stress dynamically modulates neuronal autophagy to gate depression onset
Apr .15.2025
Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders1. As a key modulator of brain homeostasis2, it remains elusive whether and how brain autophagy is engaged in stress dynamics. Here we discover that acute s
Translational genomics of osteoarthritis in 1,962,069 individuals Translational genomics of osteoarthritis in 1,962,069 individuals
Apr .15.2025
Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes1. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide2. As no disease-modifying treat